Potential COVID-19 treatment could increase cardiac event risk if taken with certain drugs

Common QT-prolonging medications include blood pressure drugs, opioids, particular antidepressants, antimalarial drugs and some muscle relaxers.

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” Our findings need to provide clinicians and researchers looking at azithromycin as a prospective treatment for COVID-19 time out,” Haridarshan Patel, PharmD, one of the research studys authors, said in a news release. “We discovered that if taken together with drugs that impact the electrical impulses of the heart, the combination is connected with a 40 percent increase in heart events, including fainting, heart palpitations and even heart attack.”.

Katie Adams –
Monday, September 21st, 2020

The research study happens 3 months after the FDA rescinded its emergency situation usage authorization for hydroxychloroquine, the antimalarial treatment used by some physicians as a COVID-19 treatment. The FDAs June 15 choice followed an impassioned debate in the medical community over hydroxychloroquines credibility for increasing the danger of heart occasions.

The FDA issued a caution for azithromycin in 2012 stating it might be connected to heart occasions, but subsequent studies have actually not produced definitive outcomes. A new research study carried out by scientists from the University of Illinois Chicago found that the drug itself does not increase the threat of cardiac occasions, however it could if taken in combination with a QT-prolonging drug, which refers to a drug that affects the interval in the hearts electrical rhythm called the QT interval.

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Azithromycin, an antibiotic being studied as a prospective COVID-19 treatment, could trigger cardiac events if taken in combination with drugs that impact the hearts electrical rhythm, according to research released Sept. 16 in JAMA Network Open.

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